Brian R. Keyes was born in Doylestown, Pennsylvania, in 1951, and was raised in Bucks and Hunterdon counties. He attended Solebury Private School and New Hope-Solebury High School. He graduated magna cum laude with a B.A. from Temple University in 1975, with numerous honors (Phi Beta Kappa, President's Scholar, Phi Alpha Theta) where he was elected by his peers to serve as a Director of the Honors Program. He received a JD from Temple Law School in 1978, where he graduated in the top 10% of his class.

Upon graduation, Mr Keyes joined the Doylestown firm of Eastburn and Gray, which he left to establish his own practice in 1985. Since that time, he has maintained offices in New Hope, Pennsylvania and Lambertville, New Jersey. He is admitted to practice in Pennsylvania and New Jersey, the Fed. District Courts of New Jersey and the Eastern District of Pennsylvania, and the U.S. Supreme Court. He has served on the Board of Directors of the Bucks County Bar Assn., the Community School of New Hope-Solebury, the Riverside Symphonia (where he served as Chairman of the Board and now serves on the Advisory Board), Concordia Chamber Players, The Aquetong Watershed Association (of which he was a founding director and has served as President), and has served as Chair of the Real Estate (2 times) and Orphans Court Sections of the Bucks County Bar Assn. He has taught courses in various venues in the areas of real estate law and estate planning and administration. In 1988 he received an award for leading the bar in the development of on-line access to the Bucks County Courthouse databases. Mr. Keyes is a frequent volunteer in the Wills for Heroes program, which provides free basic estate planning documents, such as wills and powers of attorney, to police, fire and emergency medical personnel.

Brian has two grown sons, John Keyes and Ross Keyes, and lives with his wife, artist Lisa Gladden Keyes, in Solebury Township, where Lisa has a studio for the creation of her own art and the restoration and conservation of fine art. Brian and Lisa are active members of the Solebury Township Historical Society, the New Hope Historical Society, the Michener Art Museum, the Phillips Mill Community Association and the Bucks County Audobon Society, and sing madrigals, motets and other works with a local a capella group, the Lambertville Traditional Carol Society.